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1

Artificial Intelligence (AI): Multidisciplinary perspectives on emerging challenges, opportunities, and agenda for research, practice and policy

Dwivedi, Yogesh K., Hughes, Laurie, Ismagilova, Elvira, Aarts, Gert, Coombs, Crispin, Crick, Tom, Duan, Yanqing, Dwivedi, Rohita, Edwards, John, Eirug, Aled, Galanos, Vassilis, Ilavarasan, P. Vigneswa

Journal:

International Journal of Information Management

Year:

2019

Language:

english

File:

PDF, 1.78 MB

english, 2019

2

Too many roads not taken

Edwards, Aled M., Isserlin, Ruth, Bader, Gary D., Frye, Stephen V., Willson, Timothy M., Yu, Frank H.

Journal:

Year:

2011

Language:

english

File:

PDF, 504 KB

english, 2011

3

What is the functional mobility and quality of life in patients with cerebral palsy following single-event multilevel surgery?

Edwards, Tomos Aled, Prescott, Robin John, Stebbins, Julie, Wright, James, Theologis, Tim

Journal:

Journal of Children's Orthopaedics

Year:

2020

File:

PDF, 881 KB

2020

4

Deep trefoil knot implicated in RNA binding found in an archaebacterial protein

Thomas I. Zarembinski, Youngchang Kim, Kelly Peterson, Dinesh Christendat, Akil Dharamsi, Cheryl H. Arrowsmith, Aled M. Edwards, Andrzej Joachimiak

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2003

Language:

english

File:

PDF, 769 KB

english, 2003

5

Inducing fractures and increasing cleat apertures in a bituminous coal under isotropic stress via application of microwave energy

Hemant Kumar, Edward Lester, Sam Kingman, Richard Bourne, Claudio Avila, Aled Jones, John Robinson, Phillip M. Halleck, Jonathan P. Mathews

Journal:

International Journal of Coal Geology

Year:

2011

Language:

english

File:

PDF, 1.11 MB

english, 2011

6

Large-Scale Structural Biology of the Human Proteome

Journal:

Annual Review of Biochemistry

Year:

2009

Language:

english

File:

PDF, 8.80 MB

english, 2009

7

Three-dimensional structure of yeast RNA polymerase II at 16 Å resolution

Seth A. Darst, Aled M. Edwards, Elizabeth W. Kubalek, Roger D. Kornberg

Journal:

Year:

1991

Language:

english

File:

PDF, 9.47 MB

english, 1991

8

A generalizable pre-clinical research approach for orphan disease therapy

Chandree L Beaulieu, Mark E Samuels, Sean Ekins, Christopher R McMaster, Aled M Edwards, Adrian R Krainer, Geoffrey G Hicks, Brendan J Frey, Kym M Boycott, Alex E MacKenzie

Journal:

Orphanet Journal of Rare Diseases

Year:

2012

Language:

english

File:

PDF, 297 KB

english, 2012

9

Structural Proteomics: Toward High-Throughput Structural Biology as a Tool in Functional Genomics

Yee, Adelinda, Pardee, Keith, Christendat, Dinesh, Savchenko, Alexei, Edwards, Aled M., Arrowsmith, Cheryl H.

Journal:

Accounts of Chemical Research

Year:

2003

Language:

english

File:

PDF, 270 KB

english, 2003

10

Psychological Sequelae of Surgery in a Prospective Cohort of Patients from Three Intraoperative Awareness Prevention Trials

Whitlock, Elizabeth L., Rodebaugh, Thomas L., Hassett, Afton L., Shanks, Amy M., Kolarik, Ellen, Houghtby, Janet, West, Hannah M., Burnside, Beth A., Shumaker, Erik, Villafranca, Alex, Edwards, W. Ale

Journal:

Anesthesia & Analgesia

Year:

2015

Language:

english

File:

PDF, 610 KB

english, 2015

11

Cognitive Functioning and Brain MRI in Patients with Type 1 and Type 2 Diabetes Mellitus: A Comparative Study

Brands, Augustina M.A., Biessels, Geert Jan, Kappelle, L. Jaap, de Haan, Edward H.F., de Valk, Harold W., Algra, Ale, Kessels, Roy P.C.

Journal:

Dementia and Geriatric Cognitive Disorders

Year:

2007

Language:

english

File:

PDF, 158 KB

english, 2007

12

A Call for Systematic Research on Solute Carriers

César-Razquin, Adrián, Snijder, Berend, Frappier-Brinton, Tristan, Isserlin, Ruth, Gyimesi, Gergely, Bai, Xiaoyun, Reithmeier, Reinhart A., Hepworth, David, Hediger, Matthias A., Edwards, Aled M., Sup

Journal:

Year:

2015

Language:

english

File:

PDF, 1.70 MB

english, 2015

13

Direct MBE growth of metamorphic nBn infrared photodetectors on 150 mm Ge-Si substrates for heterogeneous integration

Fastenau, Joel M., Lubyshev, Dmitri, Nelson, Scott A., Fetters, Matthew, Krysiak, Hubert, Zeng, Joe, Kattner, Michael, Frey, P., Liu, Amy W. K., Morgan, Aled O., Edwards, Stuart A., Dennis, Richard, B

Journal:

Journal of Vacuum Science & Technology B: Microelectronics and Nanometer Structures

Year:

2019

Language:

english

File:

PDF, 1.65 MB

english, 2019

14

Evaluating kratom alkaloids using PHASE

Ellis, Christopher R., Racz, Rebecca, Kruhlak, Naomi L., Kim, Marlene T., Zakharov, Alexey V., Southall, Noel, Hawkins, Edward G., Burkhart, Keith, Strauss, David G., Stavitskaya, Lidiya, Lodola, Ales

Journal:

Year:

2020

File:

PDF, 1.08 MB

2020

15

Structural Proteomics: Toward High-Throughput Structural Biology as a Tool in Functional Genomics

Adelina Yee, Keith Pardee, Dinesh Christendat, Alexei Savchenko, Aled M. Edwards, Cheryl H. Arrowsmith

Journal:

Year:

2003

File:

PDF, 57 KB

2003

16

Enzyme genomics: Application of general enzymatic screens to discover new enzymes

Ekaterina Kuznetsova, Michael Proudfoot, Stephen A. Sanders, Jeffrey Reinking, Alexei Savchenko, Cheryl H. Arrowsmith, Aled M. Edwards, Alexander F. Yakunin

Journal:

FEMS Microbiology Reviews

Year:

2005

Language:

english

File:

PDF, 383 KB

english, 2005

17

Structural proteomics: a tool for genome annotation

Alexander F Yakunin, Adelinda A Yee, Alexei Savchenko, Aled M Edwards, Cheryl H Arrowsmith

Journal:

Current Opinion in Chemical Biology

Year:

2004

Language:

english

File:

PDF, 150 KB

english, 2004

18

NMR structure of the hypothetical protein encoded by the YjbJ gene from Escherichia coli

Antonio Pineda-Lucena, Jack Liao, Bin Wu, Adelinda Yee, John R. Cort, Michael A. Kennedy, Aled. M. Edwards, Cheryl H. Arrowsmith

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2002

Language:

english

File:

PDF, 275 KB

english, 2002

19

Crystal structure of Methanobacterium thermoautotrophicum conserved protein MTH1020 reveals an NTN-hydrolase fold

Vivian Saridakis, Dinesh Christendat, Anders Thygesen, Cheryl H. Arrowsmith, Aled M. Edwards, Emil F. Pai

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2002

Language:

english

File:

PDF, 349 KB

english, 2002

20

NMR structure of the Escherichia coli protein YacG: A novel sequence motif in the zinc-finger family of proteins

Theresa A. Ramelot, John R. Cort, Adelinda A. Yee, Anthony Semesi, Aled M. Edwards, Cheryl H. Arrowsmith, Michael A. Kennedy

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2002

Language:

english

File:

PDF, 286 KB

english, 2002

21

Crystal structure of MTH169, a crucial component of phosphoribosylformylglycinamidine synthetase

Renu Batra, Dinesh Christendat, Aled Edwards, Cheryl Arrowsmith, Liang Tong

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2002

Language:

english

File:

PDF, 528 KB

english, 2002

22

Conserved protein YecM from Escherichia coli shows structural homology to metal-binding isomerases and oxygenases

Rong-Guang Zhang, Norma Duke, Roman Laskowski, Elena Evdokimova, Tatiana Skarina, Aled Edwards, Andrzej Joachimiak, Alexei Savchenko

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2003

Language:

english

File:

PDF, 155 KB

english, 2003

23

Crystal structures of MTH1187 and its yeast ortholog YBL001c

Xiao Tao, Reza Khayat, Dinesh Christendat, Alexei Savchenko, Xiaohui Xu, Sharon Goldsmith-Fischman, Barry Honig, Aled Edwards, Cheryl H. Arrowsmith, Liang Tong

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2003

Language:

english

File:

PDF, 190 KB

english, 2003

24

X-ray crystal structure of CutA from Thermotoga maritima at 1.4 Å resolution

Alexei Savchenko, Tatiana Skarina, Elena Evdokimova, James D. Watson, Roman Laskowski, Cheryl H. Arrowsmith, Aled M. Edwards, Andrzej Joachimiak, Rong-guang Zhang

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2004

Language:

english

File:

PDF, 285 KB

english, 2004

25

Functional interaction of 13 yeast SCF complexes with a set of yeast E2 enzymes in vitro

Bart M. Kus, Catherine E. Caldon, Ronit Andorn-Broza, Aled M. Edwards

Journal:

Proteins: Structure, Function, and Bioinformatics

Year:

2004

Language:

english

File:

PDF, 564 KB

english, 2004

26

RPB7, one of two dissociable subunits of yeast RNA polymerase II, is essential for cell viability

Keith McKune, Kristy L. Richards, Aled M. Edwards, Richard A. Young, Nancy A. Woychik

Journal:

Year:

1993

Language:

english

File:

PDF, 452 KB

english, 1993

27

Crystal structure of the hypothetical protein TA1238 fromThermoplasma acidophilum: a new type of helical super-bundle

Ruslan Sanishvili, Micha Pennycooke, Jun Gu, Xiaohui Xu, Andrzej Joachimiak, Aled M. Edwards, Dinesh Christendat

Journal:

Journal of Structural and Functional Genomics

Year:

2005

Language:

english

File:

PDF, 498 KB

english, 2005

28

High-throughput production of prokaryotic membrane proteins

Elena Dobrovetsky, Ming Liang Lu, Ronit Andorn-Broza, Galina Khutoreskaya, James E. Bray, Alexei Savchenko, Cheryl H. Arrowsmith, Aled M. Edwards, Christopher M. Koth

Journal:

Journal of Structural and Functional Genomics

Year:

2005

Language:

english

File:

PDF, 355 KB

english, 2005

29

Crystal structure of the hypothetical protein TA1238 fromThermoplasma acidophilum: A new type of helical super-bundle

Ruslan Sanishvili, Micha Pennycooke, Jun Gu, Xiaohui Xu, Andrzej Joachimiak, Aled M. Edwards, Dinesh Christendat

Journal:

Journal of Structural and Functional Genomics

Year:

2005

Language:

english

File:

PDF, 336 KB

english, 2005

30

Crystal structure of secretory protein Hcp3 fromPseudomonas aeruginosa

Jerzy Osipiuk, Xiaohui Xu, Hong Cui, Alexei Savchenko, Aled Edwards, Andrzej Joachimiak

Journal:

Journal of Structural and Functional Genomics

Year:

2011

Language:

english

File:

PDF, 823 KB

english, 2011

31

Crystal structure of a putative transcriptional regulator SCO0520 fromStreptomyces coelicolorA3(2)reveals an unusual dimer among TetR family proteins

Ekaterina V. Filippova, Maksymilian Chruszcz, Marcin Cymborowski, Jun Gu, Alexei Savchenko, Aled Edwards, Wladek Minor

Journal:

Journal of Structural and Functional Genomics

Year:

2011

Language:

english

File:

PDF, 2.19 MB

english, 2011

32

Galaxy Zoo: dust in spiral galaxies

Karen L. Masters, Robert Nichol, Steven Bamford, Moein Mosleh, Chris J. Lintott, Dan Andreescu, Edward M. Edmondson, William C. Keel, Phil Murray, M. Jordan Raddick, Kevin Schawinski, Anže Slosar, Ale

Journal:

Monthly Notices of the Royal Astronomical Society

Year:

2010

Language:

english

File:

PDF, 6.10 MB

english, 2010

33

Phosphorylation of Myelin-Associated Glycoprotein In Vivo and In Vitro Occurs Only in the Cytoplasmic Domain of the Large Isoform

Aled M. Edwards, Peter E. Braun, John C. Bell

Journal:

Journal of Neurochemistry

Year:

1989

Language:

english

File:

PDF, 482 KB

english, 1989

34

Gene expression profiling of early primary biliary cirrhosis: possible insights into the mechanism of action of ursodeoxycholic acid

Limin Chen, Ivan Borozan, Piotr Milkiewicz, Jing Sun, Xiangbin Meng, Catalina Coltescu, Aled M. Edwards, Mario A. Ostrowski, Maha Guindi, Elizabeth J. Heathcote, Ian D. McGilvray

Journal:

Liver International

Year:

2008

Language:

english

File:

PDF, 255 KB

english, 2008

35

Structure of the single-stranded-DNA-binding domain of replication protein A bound to DNA

Bochkarev, Alexey, Pfuetzner, Richard A., Edwards, Aled M., Frappier, Lori

Journal:

Year:

1997

File:

PDF, 1.89 MB

1997

36

10.1038/80751

Edwards, Aled M., Arrowsmith, Cheryl H., Christendat, Dinesh, Dharamsi, Akil, Friesen, James D., Greenblatt, Jack F., Vedadi, Masoud

Journal:

Natural Structural Biology

Year:

2000

Language:

english

File:

PDF, 128 KB

english, 2000

37

10.1038/82823

Edwards, Aled M., Arrowsmith, Cheryl H., Christendat, Dinesh, Yee, Adelinda, Dharamsi, Akil, Kluger, Yuval, Savchenko, Alexei, Cort, John R., Booth, Valerie, Mackereth, Cameron D., Saridakis, Vivian,

Journal:

Natural Structural Biology

Year:

2000

Language:

english

File:

PDF, 473 KB

english, 2000

38

Crystal structure of the CorA Mg2+ transporter

Lunin, Vladimir V., Dobrovetsky, Elena, Khutoreskaya, Galina, Zhang, Rongguang, Joachimiak, Andrzej, Doyle, Declan A., Bochkarev, Alexey, Maguire, Michael E., Edwards, Aled M., Koth, Christopher M.

Journal:

Year:

2006

Language:

english

File:

PDF, 660 KB

english, 2006

39

Open access chemical and clinical probes to support drug discovery

Edwards, Aled M, Bountra, Chas, Kerr, David J, Willson, Timothy M

Journal:

Nature Chemical Biology

Year:

2009

Language:

english

File:

PDF, 142 KB

english, 2009

40

In situ proteolysis for protein crystallization and structure determination

Dong, Aiping, Xu, Xiaohui, Edwards, Aled M, Chang, Changsoo, Chruszcz, Maksymilian, Cuff, Marianne, Cymborowski, Marcin, Di Leo, Rosa, Egorova, Olga, Evdokimova, Elena

Journal:

Year:

2007

Language:

english

File:

PDF, 121 KB

english, 2007

41

Epitaxial growth of protein crystals on lipid layers

Edward, Aled M., Darst, Seth A., Hemming, Sally A., Li, Yang, Kornberg, Roger D.

Journal:

Natural Structural Biology

Year:

1994

File:

PDF, 385 KB

1994

42

The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor

Korolev, Sergey, Ikeguchi, Yoshihiko, Skarina, Tatiana, Beasley, Steven, Arrowsmith, Cheryl, Edwards, Aled, Joachimiak, Andrzej, Pegg, Anthony E., Savchenko, Alexei

Journal:

Natural Structural Biology

Year:

2001

Language:

english

File:

PDF, 1.70 MB

english, 2001

43

Bermuda Principles meet structural biology

Journal:

Nature Structural and Molecular Biology

Year:

2008

Language:

english

File:

PDF, 70 KB

english, 2008

44

Letter to the Editor: 1H, 15N and 13C resonance assignments for the C-terminal protein interaction region of the 32

Georges Mer, Aled M. Edwards, Walter J. Chazin

Journal:

Journal of Biomolecular NMR

Year:

2000

Language:

english

File:

PDF, 32 KB

english, 2000

45

NMR Structure Determination and Structure-Based Functional Characterization of Conserved Hypothetical Protein MTH1175 fromMethanobacterium thermoautotrophicum

John R. Cort, Adelinda Yee, Aled M. Edwards, Cheryl H. Arrowsmith, Michael A. Kennedy

Journal:

Journal of Structural and Functional Genomics

Year:

2000

Language:

english

File:

PDF, 1.63 MB

english, 2000

46

Letter to the Editor: NMR-based structure of the conserved protein MTH865 from the Archaeon Methanobacterium thermoautotrophicum

Gregory M. Lee, Aled M. Edwards, Cheryl H. Arrowsmith, Lawrence P. McIntosh

Journal:

Journal of Biomolecular NMR

Year:

2001

Language:

english

File:

PDF, 126 KB

english, 2001

47

Letter to the Editor: Solution structure of the hypothetical protein MTH0637 fromMethanobacterium thermoautotrophicum

Antonio Pineda-Lucena, Gwan-Su Yi, Xiaoqing Chang, John R. Cort, Michael A. Kennedy, Aled.M. Edwards, Cheryl H. Arrowsmith

Journal:

Journal of Biomolecular NMR

Year:

2002

Language:

english

File:

PDF, 117 KB

english, 2002

48

Altered expression of genes involved in hepatic morphogenesis and fibrogenesis are identified by cDNA microarray analysis in biliary atresia

Limin Chen, Andrew Goryachev, Jin Sun, Peter Kim, Hui Zhang, M.James Phillips, Pascale Macgregor, Sylvie Lebel, Aled M. Edwards, Qiongfang Cao, Katryn N. Furuya

Journal:

Year:

2003

Language:

english

File:

PDF, 344 KB

english, 2003

49

Target Selection and Determination of Function in Structural Genomics

James Watson, Annabel Todd, James Bray, Roman Laskowski, Aled Edwards, Andrzej Joachimiak, Christine Orengo, Janet Thornton

Journal:

Year:

2003

Language:

english

File:

PDF, 236 KB

english, 2003

50

A novel member of the split βαβ fold: Solution structure of the hypothetical protein YML108W from Saccharomyces cerevisiae

Antonio Pineda-Lucena, Jack C.C. Liao, John R. Cort, Adelinda Yee, Michael A. Kennedy, Aled. M. Edwards, Cheryl H. Arrowsmith

Journal:

Protein Science

Year:

2003

Language:

english

File:

PDF, 214 KB

english, 2003